Genre and place in the book. A maxim on the familiarity of all that happens, with a seasonal simile. It strips events of "novelty" — the chief source of shock (see EXERCISEpraemeditatio).
Familiar as the rose in spring. σύνηθες καὶ γνώριμον — "customary and familiar." The seasonal analogy: the rose in spring, fruit in summer — each in its season, occasioning no surprise. Just so, "in season," come disease, death, calumny, treachery — the ordinary course of things, not the intrusion of anything unheard-of.
γνώριμον — "the familiar." A direct echo of the amor fati formula in 04-33 (διάθεσις ἀσπαζομένη πᾶν τὸ συμβαῖνον ὡς… γνώριμον — the disposition welcoming all that happens as "familiar"). The knowledge that an event is nothing new disarms passion: its fuel is suddenness (cf. Med. 7.1 — "there is nothing new; all is familiar and short-lived").
Fools and the wise. ὅσα τοὺς μωροὺς εὐφραίνει ἢ λυπεῖ — "whatever gladdens or grieves fools." The fool is gripped by passions (now elated, now contracted) before the ordinary; the wise see in the same things only nature's course and are unmoved. (λυπεῖ is the verb of λύπη, but here in passing, paired with εὐφραίνει; the passage is not about the passion as such — hence I do not tag the term.)
The disciplines. The principal one is desire: readiness to accept the expected, neither clinging nor recoiling. The secondary is assent: the right judgement — all this is familiar, nothing new, and no evil.
The exercise. EXERCISEThe premeditation of ills: disease, death, calumny, treachery — the canonical praemeditatio list; what is foreseen loses its novelty and is met without shock.
Parallels. Nothing new, all familiar — Med. 7.1 (cf. EXERCISEpraemeditatio). To anticipate difficulties — 02-01 (the morning "I shall meet the meddler, the ingrate…"). To accept all as familiar — 04-33 (cf. amor-fati).