Genre and place in the book. A cluster of compressed maxims (like 04-22) — a quick run across the disciplines. "You have seen those; look at these too": a turn to a new set of rules.
Be simple; do not over-complicate. σεαυτὸν μὴ τάρασσε· ἅπλωσον σεαυτόν — do not disturb yourself, make yourself simple. Disturbance is born of complication; simplicity (ἁπλότης) is peace.
The wrongdoer wrongs himself. ἁμαρτάνει τις; ἑαυτῷ TERMἁμαρτάνει — another's TERMfault falls on the doer himself (it spoils his own ruling part), not on you. The verbatim twin is Med. 9.4: "He who does wrong does wrong against himself." This is the obverse of DOGMAinvulnerability: the harm stays with the guilty and does not reach you.
All spun for you from the Whole. συμβέβηκέ τι; καλῶς — "has it happened? good," for everything was "co-fated and spun" (συγκαθείμαρτο, συνεκλώθετο — the TERMεἱμαρ- root plus the Fates' spinning) for you from the Whole from the beginning. Acceptance of fate (DOGMAamor-fati; cf. Med. 3.4 — τὰ ἑαυτῷ ἐκ τῶν ὅλων συγκλωθόμενα, literally "what is spun for him out of the whole").
Life is short — seize the present. βραχὺς ὁ βίος → κερδαντέον TERMτὸ παρόν σὺν εὐλογιστίᾳ καὶ δίκῃ: from brevity follows the "profit" of the present, taken with sound reasoning (εὐλογιστία) and justice (δίκη). The memory of brevity + the use of the present (EXERCISEmeditatio-mortis + EXERCISEprosokhe; cf. 04-17).
Sober, yet not tense. νῆφε ἀνειμένως — an oxymoron of measure: stay awake (νῆφε, "be sober"), but without strain (ἀνειμένως, "in a slackened way"). Neither distraction nor rigidity.
The disciplines. The principal one is desire: equanimity, acceptance of fate, measure. The secondary is action: to turn the present to profit with reason and justice.
Parallels. The wrongdoer harms himself — Med. 9.4; 04-08 (cf. DOGMAno-harm-to-virtuous). All spun by fate — Med. 3.4; 5.8; 10.5 (cf. TERMheimarmene, DOGMAamor-fati). Life is short, seize the present — 04-17; 03-10 (cf. TERMparon, EXERCISEmeditatio-mortis). Sobriety without strain — the measure of an active life.