Genre and place in the book. A terse maxim — almost a logical "theorem" on the value-neutrality of TERMchange. It continues the book's "mutability" thread (04-36 — Nature loves change; 04-39 — the criterion of indifference) and dissolves the fear of death from both ends at once.

A mirror symmetry. The structure is mirrored: nothing is TERMκακόν for what perishes "in change" (ἐν μεταβολῇ γινομένοις), as nothing is TERMἀγαθόν for what comes to be "out of change" (ἐκ μεταβολῆς ὑφισταμένοις). One and the same process — TERMμεταβολή — both destroys and brings forth; and since it is in itself value-neutral, neither is perishing an evil, nor is coming-to-be / existence a good.

Against the fear of death. If dying is only change, and change carries no evil, then death is nothing to fear (cf. Med. 9.3 — death is "an operation of nature" and "no evil"; life itself is a sequence of changes-"deaths"; 9.35 — loss is nothing but change). The mirror half also deflates the clinging to existence: since to arise "out of change" is no good, there is nothing to cling to in being.

The implied premise. Good and evil lie not in nature's processes (birth, death, transformation) but only in virtue and vice; all else is indifferent. It is on this premise (DOGMAonly virtue is the good) that the verdict "neither evil nor good" rests.

The disciplines. The principal one is assent: the verdict on value — change is neutral, neither evil nor good. The secondary is desire: hence fearlessness before death and a refusal to cling to existence.

Parallels. Change is neither evil nor good — 04-39; Med. 9.35 (cf. TERMmetabole). Death is only a change, an operation of nature, no evil — 04-05; 04-14; Med. 9.3.