Place in the book. A major passage on fate and its acceptance — one of the fullest formulations of the discipline of desire in the corpus. Marcus builds a whole chain: the medical analogy → the image of "fitting" → the cosmology of a single cause → the twofold ground for loving what happens.
The Asclepius analogy. "Prescribed" (συνέταξεν): as the healing god prescribes horse-riding, cold baths, going barefoot — things unpleasant but curative — so the TERMNature of the Whole "prescribes" disease, maiming, loss, as suited to your TERMdestiny (εἱμαρμένη). The frame is medical: the harsh is accepted "in the hope of health" (τῇ ἐλπίδι τῆς ὑγιείας).
Fitting and the one harmony. A play on συμβαίνειν — at once "to happen" and "to fit together": as builders say the squared stones "fit" (συμβαίνειν) one another in a wall or pyramid, so events "fit" us. "There is one harmony" (ἁρμονία μία): DOGMAas the cosmos is made one body out of all bodies, so fate is made one cause out of all causes. One's personal lot is a joint in this masonry.
Even the simple know. The folk saying "fate brought this to him" (τοῦτο ἔφερεν αὐτῷ) is the same intuition of a causal order. So one must accept it as the prescriptions of Asclepius: much is "rough" (τραχέα), yet curative.
Welcoming what happens. Let the accomplishment of the common nature's designs be to you as your own health — and then "DOGMAwelcome all that happens" (ἀσπάζου πᾶν τὸ γινόμενον), even the harsh (ἀπηνέστερον), because it leads to the health of the cosmos and to the "good faring" (εὐοδία) of Zeus. Nothing comes to a part unless it profits the Whole.
Two grounds for love (στέργειν). (1) Personal: the event was spun (συγκλωθόμενον) for you out of the "most ancient causes" — cf. Med. 10.5 ("prepared from eternity") and 7.57 ("love only what happens and is spun with your destiny"). (2) Cosmic: your lot is a cause of the well-faring and the very continuance (συμμονή) of the Whole. Hence the sharp conclusion: by discontent (δυσαρεστεῖν) you "cut through" (διακόπτεις) the connection of causes and "maim" (πηροῦται) the Whole — like a limb severed from the body (cf. Med. 8.34, body-parts).
Discipline and parallels. The principal discipline is desire: DOGMAconsent to fate as "love of what happens" (φιλεῖν τὸ συμβαῖνον). The term is TERMheimarmene (fate = providence = the reason of the cosmos). Parallels: Med. 7.57; 10.5; 8.34; 2.2; 4.34.