Genre and place in the book. A maxim of physics-theology, part of the opening cluster of Book VI (06-01, 06-04, 06-05): everything is brought to pass by the single cosmic Nature. The verb περαίνεται ("to be brought to completion, accomplished") is the same as in 06-01. The principal discipline is desire: if everything issues from one immanent Nature of which I am a part, then what happens to me is to be trusted.

The nature of the Whole (τῶν ὅλων φύσις). "Each thing is accomplished according to TERMthe nature of the Whole." The cosmic Nature — which is also the Logos, god, DOGMAprovidence — is the sole principle by which all things are "brought to their end." περαίνεται carries a teleological note: not merely to happen, but to be brought to completion.

The threefold denial. The heart of the passage is the refusal to admit any other nature besides the cosmic one. Marcus lists three conceivable options and rejects them all: (1) a nature "comprehending from outside" (ἔξωθεν περιέχουσαν) — a transcendent principle enclosing the cosmos from without (a creator outside the world); (2) a nature "comprehended within" (ἐμπεριεχομένην ἔνδον) — some distinct principle hidden inside the cosmos (a world-soul taken as separate, or Platonic Forms); (3) a nature "external and detached" (ἔξω ἀπηρτημένην) — a principle set apart outside (the Epicurean gods in the intermundia, having no part in the world). None of them governs things.

Stoic immanentism. The point of the denial is pure monism: the divine is not separate from the world but is the world's own nature. There is no "outside" from which another nature could govern. It is the same immanent divinity as in 06-01 (the governing Logos — not a transcendent creator). Hence the discipline of desire: since all follows from the one Nature in which I share, what befalls me is κατὰ φύσιν and to be accepted (cf. 05-08 — the nature of the Whole "prescribes" what happens, for the health of the world).

Disciplines and parallels. The principal one is desire (trust in the single immanent Nature). Parallels: 06-01 (all is brought to pass by the governing Logos); 05-08 (the nature of the Whole assigns what happens); Med. 4.40 (the world as one living being, one nature); 7.9 (all things interwoven; one god pervading all). The Stoic immanence of the divine — LS 44; the doctrines of DOGMAthe unity of the cosmos and DOGMAprovidence.