The torrent and the "snotty" affairs. The opening is an image of flux: χειμάρρους ἡ τῶν ὅλων οὐσία, "the substance of the Whole is a winter torrent," sweeping everything along (cf. the river of time, 5.23). Against it, "political affairs" and the "little men" (ἀνθρώπια) who fancy themselves philosophers are "paltry, full of snot" (μυξῶν μεστά). The tone is sharp, almost disgusted.
The modest work. Hence a programme without illusions: DOGMAdo what nature now demands, EXERCISEset to work if it is granted, and DOGMAdo not look around to see if anyone notices. Do not expect "PERSONPlato's Republic" — be content with the smallest advance; you cannot change another's δόγμα, and without a change of dogmas there remains only "the slavery of those who groan and feign obedience." The exempla — PERSONAlexander the Great, Philip II, Demetrius of Phalerum — are summoned and dismissed: if they "played tragedy" (ἐτραγῴδησαν), no one bids you imitate them. The closing motto: "simple and modest (ἁπλοῦν καὶ αἰδῆμον) is the work of philosophy — do not drag me off into pomposity (σεμνοτυφία)." The governing discipline is action.